Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways

Myeloid malignancies bearing chromosomal inv(3)/t(3;3) abnormalities are among the most therapy-resistant leukemias. Deregulated expression of EVI1 is the molecular hallmark of this disease; however, the genome-wide spectrum of cooperating mutations in this disease subset has not been systematically...

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Publicat a:Blood
Autors principals: Gröschel, Stefan, Sanders, Mathijs A., Hoogenboezem, Remco, Zeilemaker, Annelieke, Havermans, Marije, Erpelinck, Claudia, Bindels, Eric M. J., Beverloo, H. Berna, Döhner, Hartmut, Löwenberg, Bob, Döhner, Konstanze, Delwel, Ruud, Valk, Peter J. M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334729/
https://ncbi.nlm.nih.gov/pubmed/25381062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-591461
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