MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

The tendency of 5-methylcytosine (5mC) to undergo spontaneous deamination has had a major role in shaping the human genome, and this methylation damage remains the primary source of somatic mutations that accumulate with age. How 5mC deamination contributes to cancer risk in different tissues remain...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Sanders, Mathijs A., Chew, Edward, Flensburg, Christoffer, Zeilemaker, Annelieke, Miller, Sarah E., al Hinai, Adil S., Bajel, Ashish, Luiken, Bram, Rijken, Melissa, Mclennan, Tamara, Hoogenboezem, Remco M., Kavelaars, François G., Fröhling, Stefan, Blewitt, Marnie E., Bindels, Eric M., Alexander, Warren S., Löwenberg, Bob, Roberts, Andrew W., Valk, Peter J. M., Majewski, Ian J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2018
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172562/
https://ncbi.nlm.nih.gov/pubmed/30049810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-05-852566
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