Mutant allelic burden in acute myeloid leukaemia: Why bother?

Por Touw, Ivo P., Sanders, Mathijs A.
Publicado no Br J Haematol (2019)

The Landscape of KMT2A-PTD AML: Concurrent Mutations, Gene Expression Signatures, and Clinical Outcome

Por Hinai, Adil S.A. Al, Pratcorona, Marta, Grob, Tim, Kavelaars, François G., Bussaglia, Elena, Sanders, Mathijs A., Nomdedeu, Josep, Valk, Peter J.M.
Publicado no Hemasphere (2019)

SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levels

Por Sanders, Mathijs A, Verhaak, Roel GW, Geertsma-Kleinekoort, Wendy MC, Abbas, Saman, Horsman, Sebastiaan, van der Spek, Peter J, Löwenberg, Bob, Valk, Peter JM
Publicado em 2008

RNA sequencing reveals a unique fusion of the lysine (K)-specific methyltransferase 2A and smooth muscle myosin heavy chain 11 in myelodysplastic syndrome and acute myeloid leukemi...

Por Sanders, Mathijs A., Kavelaars, François G., Zeilemaker, Annelieke, Al Hinai, Adil S.A., Abbas, Saman, Beverloo, H. Berna, van Lom, Kirsten, Valk, Peter J.M.
Publicado no Haematologica (2015)

HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics

Por Verhaak, Roel GW, Sanders, Mathijs A, Bijl, Maarten A, Delwel, Ruud, Horsman, Sebastiaan, Moorhouse, Michael J, van der Spek, Peter J, Löwenberg, Bob, Valk, Peter JM
Publicado em 2006

Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value

Por Pratcorona, Marta, Abbas, Saman, Sanders, Mathijs A., Koenders, Jasper E., Kavelaars, François G., Erpelinck-Verschueren, Claudia A.J., Zeilemakers, Annelieke, Löwenberg, Bob, Valk, Peter J.M.
Publicado em 2012

Expression profiling of adult acute lymphoblastic leukemia identifies a BCR-ABL1-like subgroup characterized by high non-response and relapse rates

Por Boer, Judith M., Koenders, Jasper E., van der Holt, Bronno, Exalto, Carla, Sanders, Mathijs A., Cornelissen, Jan J., Valk, Peter J.M., den Boer, Monique L., Rijneveld, Anita W.
Publicado no Haematologica (2015)

Lethal neonatal bone marrow failure syndrome with multiple congenital abnormalities, including limb defects, due to a constitutional deletion of 3′ MECOM

Por van der Veken, Lars T., Maiburg, Merel C., Groenendaal, Floris, van Gijn, Mariëlle E., Bloem, Andries C., Erpelinck, Claudia, Gröschel, Stefan, Sanders, Mathijs A., Delwel, Ruud, Bierings, Marc B., Buijs, Arjan
Publicado no Haematologica (2018)

Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways

Por Gröschel, Stefan, Sanders, Mathijs A., Hoogenboezem, Remco, Zeilemaker, Annelieke, Havermans, Marije, Erpelinck, Claudia, Bindels, Eric M. J., Beverloo, H. Berna, Döhner, Hartmut, Löwenberg, Bob, Döhner, Konstanze, Delwel, Ruud, Valk, Peter J. M.
Publicado no Blood (2015)

Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia

Por Polak, Roel, Bierings, Marc B., van der Leije, Cindy S., Sanders, Mathijs A., Roovers, Onno, Marchante, João R. M., Boer, Judith M., Cornelissen, Jan J., Pieters, Rob, den Boer, Monique L., Buitenhuis, Miranda
Publicado no Haematologica (2019)

Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes

Por Zambetti, Noemi A., Bindels, Eric M. J., Van Strien, Paulina M. H., Valkhof, Marijke G., Adisty, Maria N., Hoogenboezem, Remco M., Sanders, Mathijs A., Rommens, Johanna M., Touw, Ivo P., Raaijmakers, Marc H. G. P.
Publicado no Haematologica (2015)

Somatic mutations and clonal dynamics in healthy and cirrhotic human liver

Por Brunner, Simon F, Roberts, Nicola D, Wylie, Luke A, Moore, Luiza, Aitken, Sarah J, Davies, Susan E, Sanders, Mathijs A, Ellis, Pete, Alder, Chris, Hooks, Yvette, Abascal, Federico, Stratton, Michael R, Martincorena, Inigo, Hoare, Matthew, Campbell, Peter J
Publicado no Nature (2019)

Lack of splice factor and cohesin complex mutations in pediatric myelodysplastic syndrome

Por Obenauer, Julia C., Kavelaars, François G., Sanders, Mathijs A., Hoogenboezem, Remco M., de Vries, Andrica C. H., van Strien, Paulina M. H., de Haas, Valerie, Locatelli, Franco, Hasle, Henrik, Valk, Peter J. M., Touw, Ivo P., van den Heuvel-Eibrink, Marry M.
Publicado no Haematologica (2016)

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations

Por Jutzi, Jonas Samuel, Basu, Titiksha, Pellmann, Maximilian, Kaiser, Sandra, Steinemann, Doris, Sanders, Mathijs A., Hinai, Adil S. A., Zeilemaker, Annelieke, Bojtine Kovacs, Sarolta, Koellerer, Christoph, Ostendorp, Jenny, Aumann, Konrad, Wang, Wei, Raffoux, Emmanuel, Cassinat, Bruno, Bullinger, Lars, Schlegelberger, Brigitte, Valk, Peter J. M., Pahl, Heike Luise
Publicado no Blood (2019)

Somatic Evolution in Non-neoplastic IBD-Affected Colon

Por Olafsson, Sigurgeir, McIntyre, Rebecca E., Coorens, Tim, Butler, Timothy, Jung, Hyunchul, Robinson, Philip S., Lee-Six, Henry, Sanders, Mathijs A., Arestang, Kenneth, Dawson, Claire, Tripathi, Monika, Strongili, Konstantina, Hooks, Yvette, Stratton, Michael R., Parkes, Miles, Martincorena, Inigo, Raine, Tim, Campbell, Peter J., Anderson, Carl A.
Publicado no Cell (2020)

Integrated genome-wide genotyping and gene expression profiling reveals BCL11B as a putative oncogene in acute myeloid leukemia with 14q32 aberrations

Por Abbas, Saman, Sanders, Mathijs A., Zeilemaker, Annelieke, Geertsma-Kleinekoort, Wendy M.C., Koenders, Jasper E., Kavelaars, Francois G., Abbas, Zabiollah G., Mahamoud, Souad, Chu, Isabel W.T., Hoogenboezem, Remco, Peeters, Justine K., van Drunen, Ellen, van Galen, Janneke, Beverloo, H. Berna, Löwenberg, Bob, Valk, Peter J.M.
Publicado em 2014

An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation

Por Avellino, Roberto, Havermans, Marije, Erpelinck, Claudia, Sanders, Mathijs A., Hoogenboezem, Remco, van de Werken, Harmen J. G., Rombouts, Elwin, van Lom, Kirsten, van Strien, Paulina M. H., Gebhard, Claudia, Rehli, Michael, Pimanda, John, Beck, Dominik, Erkeland, Stefan, Kuiken, Thijs, de Looper, Hans, Gröschel, Stefan, Touw, Ivo, Bindels, Eric, Delwel, Ruud
Publicado no Blood (2016)

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

Por Sanders, Mathijs A., Chew, Edward, Flensburg, Christoffer, Zeilemaker, Annelieke, Miller, Sarah E., al Hinai, Adil S., Bajel, Ashish, Luiken, Bram, Rijken, Melissa, Mclennan, Tamara, Hoogenboezem, Remco M., Kavelaars, François G., Fröhling, Stefan, Blewitt, Marnie E., Bindels, Eric M., Alexander, Warren S., Löwenberg, Bob, Roberts, Andrew W., Valk, Peter J. M., Majewski, Ian J.
Publicado no Blood (2018)

Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia

Por Kühnl, Andrea, Valk, Peter J. M., Sanders, Mathijs A., Ivey, Adam, Hills, Robert K., Mills, Ken I., Gale, Rosemary E., Kaiser, Martin F., Dillon, Richard, Joannides, Melanie, Gilkes, Amanda, Haferlach, Torsten, Schnittger, Susanne, Duprez, Estelle, Linch, David C., Delwel, Ruud, Löwenberg, Bob, Baldus, Claudia D., Solomon, Ellen, Burnett, Alan K., Grimwade, David
Publicado no Blood (2015)

Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

Por Ping, Zhen, Chen, Si, Hermans, Sjoerd J. F., Kenswil, Keane J. G., Feyen, Jacqueline, van Dijk, Claire, Bindels, Eric M. J., Mylona, Athina M., Adisty, Niken M., Hoogenboezem, Remco M., Sanders, Mathijs A., Cremers, Eline M. P., Lindenbergh-Kortleve, Dicky J., Samsom, Janneke N., van de Loosdrecht, Arjan A., Raaijmakers, Marc H. G. P.
Publicado no Leukemia (2018)