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Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes

Shwachman-Diamond syndrome is a congenital bone marrow failure disorder characterized by debilitating neutropenia. The disease is associated with loss-of-function mutations in the SBDS gene, implicated in ribosome biogenesis, but the cellular and molecular events driving cell specific phenotypes in...

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書誌詳細
出版年:Haematologica
主要な著者: Zambetti, Noemi A., Bindels, Eric M. J., Van Strien, Paulina M. H., Valkhof, Marijke G., Adisty, Maria N., Hoogenboezem, Remco M., Sanders, Mathijs A., Rommens, Johanna M., Touw, Ivo P., Raaijmakers, Marc H. G. P.
フォーマット: Artigo
言語:Inglês
出版事項: Ferrata Storti Foundation 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591760/
https://ncbi.nlm.nih.gov/pubmed/26185170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.131573
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