PML-controlled responses in severe congenital neutropenia with ELANE-misfolding mutations

Mutations in ELANE cause severe congenital neutropenia (SCN), but how they affect neutrophil production and contribute to leukemia predisposition is unknown. Neutropenia is alleviated by CSF3 (granulocyte colony-stimulating factor) therapy in most cases, but dose requirements vary between patients....

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Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: Olofsen, Patricia A., Bosch, Dennis A., Roovers, Onno, van Strien, Paulina M. H., de Looper, Hans W. J., Hoogenboezem, Remco M., Barnhoorn, Sander, Mastroberardino, Pier G., Ghazvini, Mehrnaz, van der Velden, Vincent H. J., Bindels, Eric M. J., de Pater, Emma M., Touw, Ivo P.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2021
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876869/
https://ncbi.nlm.nih.gov/pubmed/33560392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003214
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