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PML-controlled responses in severe congenital neutropenia with ELANE-misfolding mutations

Mutations in ELANE cause severe congenital neutropenia (SCN), but how they affect neutrophil production and contribute to leukemia predisposition is unknown. Neutropenia is alleviated by CSF3 (granulocyte colony-stimulating factor) therapy in most cases, but dose requirements vary between patients....

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Olofsen, Patricia A., Bosch, Dennis A., Roovers, Onno, van Strien, Paulina M. H., de Looper, Hans W. J., Hoogenboezem, Remco M., Barnhoorn, Sander, Mastroberardino, Pier G., Ghazvini, Mehrnaz, van der Velden, Vincent H. J., Bindels, Eric M. J., de Pater, Emma M., Touw, Ivo P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876869/
https://ncbi.nlm.nih.gov/pubmed/33560392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003214
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