An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation

Neutrophilic differentiation is dependent on CCAAT enhancer-binding protein α (C/EBPα), a transcription factor expressed in multiple organs including the bone marrow. Using functional genomic technologies in combination with clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR-as...

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Publicado en:Blood
Main Authors: Avellino, Roberto, Havermans, Marije, Erpelinck, Claudia, Sanders, Mathijs A., Hoogenboezem, Remco, van de Werken, Harmen J. G., Rombouts, Elwin, van Lom, Kirsten, van Strien, Paulina M. H., Gebhard, Claudia, Rehli, Michael, Pimanda, John, Beck, Dominik, Erkeland, Stefan, Kuiken, Thijs, de Looper, Hans, Gröschel, Stefan, Touw, Ivo, Bindels, Eric, Delwel, Ruud
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2016
Assuntos:
Hematopoiesis and Stem Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043424/
https://ncbi.nlm.nih.gov/pubmed/26966090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-695759
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