Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

Mutations in CCAAT/enhancer binding protein α (CEBPA) are seen in 5% to 14% of acute myeloid leukemia (AML) and have been associated with a favorable clinical outcome. Most AMLs with CEBPA mutations simultaneously carry 2 mutations (CEBPA(double-mut)), usually biallelic, whereas single heterozygous...

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Hlavní autoři: Wouters, Bas J., Löwenberg, Bob, Erpelinck-Verschueren, Claudia A. J., van Putten, Wim L. J., Valk, Peter J. M., Delwel, Ruud
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2009
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662648/
https://ncbi.nlm.nih.gov/pubmed/19171880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-179895
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