Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1

DNA methylation patterns are frequently dysregulated in cancer, although little is known of the mechanisms through which specific gene sets become aberrantly methylated. The ecotropic viral integration site 1 (EVI1) locus encodes a DNA binding zinc-finger transcription factor that is aberrantly expr...

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Bibliographic Details
Main Authors: Lugthart, Sanne, Figueroa, Maria E., Bindels, Eric, Skrabanek, Lucy, Valk, Peter J. M., Li, Yushan, Meyer, Stefan, Erpelinck-Verschueren, Claudia, Greally, John, Löwenberg, Bob, Melnick, Ari, Delwel, Ruud
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037746/
https://ncbi.nlm.nih.gov/pubmed/20855866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-281337
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