DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patien...

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Detalhes bibliográficos
Main Authors: Figueroa, Maria E., Lugthart, Sanne, Li, Yushan, Erpelinck-Verschueren, Claudia, Deng, Xutao, Christos, Paul J., Schifano, Elizabeth, Booth, James, van Putten, Wim, Skrabanek, Lucy, Campagne, Fabien, Mazumdar, Madhu, Greally, John M., Valk, Peter J.M., Löwenberg, Bob, Delwel, Ruud, Melnick, Ari
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008568/
https://ncbi.nlm.nih.gov/pubmed/20060365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.11.020
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