EVI1 is critical for the pathogenesis of a subset of MLL-AF9–rearranged AMLs

The proto-oncogene EVI1 (ecotropic viral integration site-1), located on chromosome band 3q26, is aberrantly expressed in human acute myeloid leukemia (AML) with 3q26 rearrangements. In the current study, we showed, in a large AML cohort carrying 11q23 translocations, that ∼ 43% of all mixed lineage...

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Autores principales: Bindels, Eric M. J., Havermans, Marije, Lugthart, Sanne, Erpelinck, Claudia, Wocjtowicz, Elizabeth, Krivtsov, Andrei V., Rombouts, Elwin, Armstrong, Scott A., Taskesen, Erdogan, Haanstra, Jurgen R., Beverloo, H. Berna, Döhner, Hartmut, Hudson, Wendy A., Kersey, John H., Delwel, Ruud, Kumar, Ashish R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2012
Materias:
Clinical Trials and Observations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382941/
https://ncbi.nlm.nih.gov/pubmed/22553314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-393827
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