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t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL
The most frequent MLL-gene rearrangement found in leukemia is a reciprocal translocation with AF4 on chromosome 4 resulting in the formation of the MLL-AF4 and the AF4-MLL fusion genes. The oncogenic role of MLL-AF4 is documented but the significance of the reciprocal product - AF4-MLL in leukemia i...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3011030/ https://ncbi.nlm.nih.gov/pubmed/20869771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2010.08.011 |
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