EVI1 is critical for the pathogenesis of a subset of MLL-AF9–rearranged AMLs

The proto-oncogene EVI1 (ecotropic viral integration site-1), located on chromosome band 3q26, is aberrantly expressed in human acute myeloid leukemia (AML) with 3q26 rearrangements. In the current study, we showed, in a large AML cohort carrying 11q23 translocations, that ∼ 43% of all mixed lineage...

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Hlavní autoři: Bindels, Eric M. J., Havermans, Marije, Lugthart, Sanne, Erpelinck, Claudia, Wocjtowicz, Elizabeth, Krivtsov, Andrei V., Rombouts, Elwin, Armstrong, Scott A., Taskesen, Erdogan, Haanstra, Jurgen R., Beverloo, H. Berna, Döhner, Hartmut, Hudson, Wendy A., Kersey, John H., Delwel, Ruud, Kumar, Ashish R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Clinical Trials and Observations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382941/
https://ncbi.nlm.nih.gov/pubmed/22553314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-393827
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