Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

MLL-fusion proteins can induce acute myeloid leukemias (AML) from either hematopoietic stem cells (HSC) or granulocyte macrophage progenitors (GMP), but it remains unclear if the cell of origin influences the biology of the resultant leukemia. MLL-AF9 transduced single HSC or GMP could be continuous...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Krivtsov, Andrei V., Figueroa, Maria E., Sinha, Amit U., Stubbs, Matthew C., Feng, Zhaohui, Valk, Peter J.M., Delwel, Ruud, Döhner, Konstanze, Bullinger, Lars, Kung, Andrew L., Melnick, Ari M., Armstrong, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693300/
https://ncbi.nlm.nih.gov/pubmed/23235717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.363
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