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MLL-rearranged Leukemia is Dependent on Aberrant H3K79 Methylation by DOT1L
The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We identified the MLL-fusion targets in an MLL-AF9 leukemia model, and conducted epigenetic profiling for H3K79me2, H3K4me3, H3...
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Main Authors: | , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3329803/ https://ncbi.nlm.nih.gov/pubmed/21741597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.06.010 |
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