Abrogation of MLL-AF10 and CALM-AF10 mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l

The t(10;11)(p12;q23) translocation and the t(10;11)(p12;q14) translocation, which encode the MLL-AF10 and CALM-AF10 fusion oncoproteins respectively, are two recurrent chromosomal rearrangements observed in patients with acute myeloid leukemia and acute lymphoblastic leukemia. Here we demonstrate t...

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Main Authors: Chen, Liying, Deshpande, Aniruddha, Banka, Deepti, Bernt, Kathrin M., Dias, Stuart, Buske, Christian, Olhava, Edward J., Daigle, Scott R., Richon, Victoria M., Pollock, Roy M., Armstrong, Scott A.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932800/
https://ncbi.nlm.nih.gov/pubmed/23138183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.327
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