AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes

Homeotic (HOX) genes are dysregulated in multiple malignancies including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to mono-methylation (H3K79me1) at HOX loci as hematopoietic cells mature thus coinciding with a decrease in HOX gene expression. We show that...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cancer Cell
Hlavní autoři: Deshpande, Aniruddha J., Deshpande, Anagha, Sinha, Amit U., Chen, Liying, Chang, Jenny, Cihan, Ali, Fazio, Maurizio, Chen, Chun-wei, Zhu, Nan, Koche, Richard, Dzhekieva, Liuda, Ibáñez, Gloria, Dias, Stuart, Banka, Deepti, Krivtsov, Andrei, Luo, Minkui, Roeder, Robert G., Bradner, James E., Bernt, Kathrin M., Armstrong, Scott A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291116/
https://ncbi.nlm.nih.gov/pubmed/25464900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.10.009
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky