AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes

Homeotic (HOX) genes are dysregulated in multiple malignancies including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to mono-methylation (H3K79me1) at HOX loci as hematopoietic cells mature thus coinciding with a decrease in HOX gene expression. We show that...

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Pubblicato in:Cancer Cell
Autori principali: Deshpande, Aniruddha J., Deshpande, Anagha, Sinha, Amit U., Chen, Liying, Chang, Jenny, Cihan, Ali, Fazio, Maurizio, Chen, Chun-wei, Zhu, Nan, Koche, Richard, Dzhekieva, Liuda, Ibáñez, Gloria, Dias, Stuart, Banka, Deepti, Krivtsov, Andrei, Luo, Minkui, Roeder, Robert G., Bradner, James E., Bernt, Kathrin M., Armstrong, Scott A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291116/
https://ncbi.nlm.nih.gov/pubmed/25464900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.10.009
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