Genomic Dark Matter Sheds Light on EVI1-driven Leukemia

Por Koche, Richard, Armstrong, Scott A.
Publicado em 2014

Reprogramming factor expression induces rapid and widespread targeted chromatin remodeling

Por Koche, Richard P., Smith, Zachary D., Adli, Mazhar, Gu, Hongcang, Ku, Manching, Gnirke, Andreas, Bernstein, Bradley E., Meissner, Alexander
Publicado em 2011

The MicrobesOnline Web site for comparative genomics

Por Alm, Eric J., Huang, Katherine H., Price, Morgan N., Koche, Richard P., Keller, Keith, Dubchak, Inna L., Arkin, Adam P.
Publicado em 2005

GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells

Por Mendenhall, Eric M., Koche, Richard P., Truong, Thanh, Zhou, Vicky W., Issac, Biju, Chi, Andrew S., Ku, Manching, Bernstein, Bradley E.
Publicado em 2010

H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions

Por Ku, Manching, Jaffe, Jacob D, Koche, Richard P, Rheinbay, Esther, Endoh, Mitsuhiro, Koseki, Haruhiko, Carr, Steven A, Bernstein, Bradley E
Publicado em 2012

Hematopoietic differentiation is required for initiation of acute myeloid leukemia

Por Ye, Min, Zhang, Hong, Yang, Henry, Koche, Richard, Staber, Philipp B., Cusan, Monica, Levantini, Elena, Welner, Robert S., Bach, Christian S., Zhang, Junyan, Krivtsov, Andrei, Armstrong, Scott A., Tenen, Daniel G.
Publicado no Cell Stem Cell (2015)

Forward genetic screen of human transposase genomic rearrangements

Por Henssen, Anton G., Jiang, Eileen, Zhuang, Jiali, Pinello, Luca, Socci, Nicholas D., Koche, Richard, Gonen, Mithat, Villasante, Camila M., Armstrong, Scott A., Bauer, Daniel E., Weng, Zhiping, Kentsis, Alex
Publicado no BMC Genomics (2016)

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition

Por Kühn, Michael W.M., Hadler, Michael J., Daigle, Scott R., Koche, Richard P., Krivtsov, Andrei V., Olhava, Edward J., Caligiuri, Michael A., Huang, Gang, Bradner, James E., Pollock, Roy M., Armstrong, Scott A.
Publicado no Haematologica (2015)

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

Por Ku, Manching, Koche, Richard P., Rheinbay, Esther, Mendenhall, Eric M., Endoh, Mitsuhiro, Mikkelsen, Tarjei S., Presser, Aviva, Nusbaum, Chad, Xie, Xiaohui, Chi, Andrew S., Adli, Mazhar, Kasif, Simon, Ptaszek, Leon M., Cowan, Chad A., Lander, Eric S., Koseki, Haruhiko, Bernstein, Bradley E.
Publicado em 2008

MLL-AF9– and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C

Por Zhu, Nan, Chen, Mo, Eng, Rowena, DeJong, Joshua, Sinha, Amit U., Rahnamay, Noushin F., Koche, Richard, Al-Shahrour, Fatima, Minehart, Janna C., Chen, Chun-Wei, Deshpande, Aniruddha J., Xu, Haiming, Chu, S. Haihua, Ebert, Benjamin L., Roeder, Robert G., Armstrong, Scott A.
Publicado no J Clin Invest (2016)

AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes

Por Deshpande, Aniruddha J., Deshpande, Anagha, Sinha, Amit U., Chen, Liying, Chang, Jenny, Cihan, Ali, Fazio, Maurizio, Chen, Chun-wei, Zhu, Nan, Koche, Richard, Dzhekieva, Liuda, Ibáñez, Gloria, Dias, Stuart, Banka, Deepti, Krivtsov, Andrei, Luo, Minkui, Roeder, Robert G., Bradner, James E., Bernt, Kathrin M., Armstrong, Scott A.
Publicado no Cancer Cell (2014)

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Por Mikkelsen, Tarjei S., Ku, Manching, Jaffe, David B., Issac, Biju, Lieberman, Erez, Giannoukos, Georgia, Alvarez, Pablo, Brockman, William, Kim, Tae-Kyung, Koche, Richard P., Lee, William, Mendenhall, Eric, O’Donovan, Aisling, Presser, Aviva, Russ, Carsten, Xie, Xiaohui, Meissner, Alexander, Wernig, Marius, Jaenisch, Rudolf, Nusbaum, Chad, Lander, Eric S., Bernstein, Bradley E.
Publicado em 2007

ASXL1 Mutations Promote Myeloid Transformation Through Loss of PRC2-Mediated Gene Repression

Por Abdel-Wahab, Omar, Adli, Mazhar, LaFave, Lindsay M., Gao, Jie, Hricik, Todd, Shih, Alan H., Pandey, Suveg, Patel, Jay, Chung, Young Rock, Koche, Richard, Perna, Fabiana, Zhao, Xinyang, Taylor, Jordan E., Park, Christopher Y., Carroll, Martin, Melnick, Ari, Nimer, Stephen D., Jaffe, Jacob D., Aifantis, Iannis, Bernstein, Bradley E., Levine, Ross L
Publicado em 2012

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

Por Abdel-Wahab, Omar, Gao, Jie, Adli, Mazhar, Dey, Anwesha, Trimarchi, Thomas, Chung, Young Rock, Kuscu, Cem, Hricik, Todd, Ndiaye-Lobry, Delphine, LaFave, Lindsay M., Koche, Richard, Shih, Alan H., Guryanova, Olga A., Kim, Eunhee, Li, Sheng, Pandey, Suveg, Shin, Joseph Y., Telis, Leon, Liu, Jinfeng, Bhatt, Parva K., Monette, Sebastien, Zhao, Xinyang, Mason, Christopher E., Park, Christopher Y., Bernstein, Bradley E., Aifantis, Iannis, Levine, Ross L.
Publicado em 2013

Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias

Por Wang, Kai, Sanchez-Martin, Marta, Wang, Xujun, Knapp, Kristina M., Koche, Richard, Vu, Ly, Nahas, Michelle K., He, Jie, Hadler, Michael, Stein, Eytan M, Tallman, Martin S., Donahue, Amy L, Frampton, Garrett M, Lipson, Doron, Roels, Steven, Stephens, Philip J., Sanford, Eric M, Brennan, Tim, Otto, Geoff A., Yelensky, Roman, Miller, Vincent A., Kharas, Michael G., Levine, Ross L., Ferrando, Adolfo, Armstrong, Scott A., Krivtsov, Andrei V.
Publicado no Leukemia (2016)

Loss of BAP1 function leads to EZH2-dependent transformation

Por LaFave, Lindsay M., Béguelin, Wendy, Koche, Richard, Teater, Matt, Spitzer, Barbara, Chramiec, Alan, Papalexi, Efthymia, Keller, Matthew D., Hricik, Todd, Konstantinoff, Katerina, Micol, Jean-Baptiste, Durham, Benjamin, Knutson, Sarah K., Campbell, John E., Blum, Gil, Shi, Xinxu, Doud, Emma H., Krivtsov, Andrei V., Chung, Young Rock, Khodos, Inna, de Stanchina, Elisa, Ouerfelli, Ouathek, Adusumilli, Prasad S., Thomas, Paul M., Kelleher, Neil L., Luo, Minkui, Keilhack, Heike, Abdel-Wahab, Omar, Melnick, Ari, Armstrong, Scott A., Levine, Ross L.
Publicado no Nat Med (2015)

DNMT3A R882 mutations promote anthracycline resistance in acute myeloid leukemia through impaired nucleosome remodeling

Por Guryanova, Olga A., Shank, Kaitlyn, Spitzer, Barbara, Luciani, Luisa, Koche, Richard P., Garrett-Bakelman, Francine E., Ganzel, Chezi, Durham, Benjamin H., Mohanty, Abhinita, Hoermann, Gregor, Rivera, Sharon A., Chramiec, Alan G., Pronier, Elodie, Bastian, Lennart, Keller, Matthew D., Tovbin, Daniel, Loizou, Evangelia, Weinstein, Abby R., Gonzalez, Adriana Rodriguez, Lieu, Yen, Rowe, Jacob M., Pastore, Friederike, McKenney, Anna Sophia, Krivtsov, Andrei V., Sperr, Wolfgang R., Cross, Justin R., Mason, Christopher E., Tallman, Martin S., Arcila, Maria E., Abdel-Wahab, Omar, Armstrong, Scott A., Kubicek, Stefan, Staber, Philipp B., Gönen, Mithat, Paietta, Elisabeth M., Melnick, Ari M., Nimer, Stephen D., Mukherjee, Siddhartha, Levine, Ross L.
Publicado no Nat Med (2016)