Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity

A robust network of transcription factors and an open chromatin landscape are hallmarks of the naïve pluripotent state. Recently, the acetyllysine reader Brd4 has been implicated in stem cell maintenance, but the relative contribution of Brd4 to pluripotency remains unclear. Here we show that Brd4 i...

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Publicado en:Nat Cell Biol
Autores principales: Finley, Lydia W.S., Vardhana, Santosha A., Carey, Bryce W., Alonso-Curbelo, Direna, Koche, Richard, Chen, Yanyang, Wen, Duancheng, King, Bryan, Radler, Megan R., Rafii, Shahin, Lowe, Scott W., Allis, C. David, Thompson, Craig B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937285/
https://ncbi.nlm.nih.gov/pubmed/29662175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0086-3
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