Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity

A robust network of transcription factors and an open chromatin landscape are hallmarks of the naïve pluripotent state. Recently, the acetyllysine reader Brd4 has been implicated in stem cell maintenance, but the relative contribution of Brd4 to pluripotency remains unclear. Here we show that Brd4 i...

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Publicado no:Nat Cell Biol
Main Authors: Finley, Lydia W.S., Vardhana, Santosha A., Carey, Bryce W., Alonso-Curbelo, Direna, Koche, Richard, Chen, Yanyang, Wen, Duancheng, King, Bryan, Radler, Megan R., Rafii, Shahin, Lowe, Scott W., Allis, C. David, Thompson, Craig B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937285/
https://ncbi.nlm.nih.gov/pubmed/29662175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0086-3
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