Glutamine independence is a selectable feature of pluripotent stem cells

Most rapidly proliferating mammalian cells rely on the oxidation of exogenous glutamine to support cell proliferation. We previously found that culture of mouse embryonic stem cells (ESCs) in the presence of inhibitors against MEK and GSK3β to maintain pluripotency reduces cellular reliance on gluta...

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Pubblicato in:Nat Metab
Autori principali: Vardhana, Santosha A., Arnold, Paige K., Rosen, Bess P., Chen, Yanyang, Carey, Bryce W., Huangfu, Danwei, Carmona-Fontaine, Carlos, Thompson, Craig B., Finley, Lydia W.S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737941/
https://ncbi.nlm.nih.gov/pubmed/31511848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0082-3
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