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Genomic Dark Matter Sheds Light on EVI1-driven Leukemia

The orchestration of transcriptional programs depends on proper gene-enhancer pairing. While much remains to be learned about this process in normal development, two recent studies in Cell and Cancer Cell highlight how the genomic rearrangement of an enhancer plays a causal role in the onset of a le...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Koche, Richard, Armstrong, Scott A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046890/
https://ncbi.nlm.nih.gov/pubmed/24735919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.03.031
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