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NUP98-Fusion Proteins Interact With the NSL and MLL1 Complexes To Drive Leukemogenesis

The Nucleoporin 98 gene (NUP98) is fused to a variety of partner genes in multiple hematopoietic malignancies. Here we demonstrate that NUP98 fusion proteins, including NUP98-HOXA9 (NHA9), NUP98-HOXD13 (NHD13), NUP98-NSD1, NUP98-PHF23, and NUP98-TOP1 physically interact with mixed lineage leukemia 1...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Xu, Haiming, Valerio, Daria G, Eisold, Meghan E, Sinha, Amit, Koche, Richard P, Hu, Wenhuo, Chen, Chun-Wei, Chu, S Haihua, Brien, Gerard L, Park, Christopher Y., Hsieh, James J., Ernst, Patricia, Armstrong, Scott A
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501282/
https://ncbi.nlm.nih.gov/pubmed/27889185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.10.019
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