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NUP98-Fusion Proteins Interact With the NSL and MLL1 Complexes To Drive Leukemogenesis
The Nucleoporin 98 gene (NUP98) is fused to a variety of partner genes in multiple hematopoietic malignancies. Here we demonstrate that NUP98 fusion proteins, including NUP98-HOXA9 (NHA9), NUP98-HOXD13 (NHD13), NUP98-NSD1, NUP98-PHF23, and NUP98-TOP1 physically interact with mixed lineage leukemia 1...
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| Publicado no: | Cancer Cell |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5501282/ https://ncbi.nlm.nih.gov/pubmed/27889185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.10.019 |
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