Histone acetyltransferase activity of MOF is required for MLL-AF9 leukemogenesis

Chromatin-based mechanisms offer therapeutic targets in acute myeloid leukemia (AML) that are of great current interest. In this study, we conducted an RNAi-based screen to identify druggable chromatin regulator-based targets in leukemias marked by oncogenic rearrangements of the MLL gene. In this m...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Valerio, Daria G., Xu, Haiming, Chen, Chun-Wei, Hoshii, Takayuki, Eisold, Meghan E., Delaney, Christopher, Cusan, Monica, Deshpande, Aniruddha J., Huang, Chun-Hao, Lujambio, Amaia, Zheng, George, Zuber, Johannes, Pandita, Tej K., Lowe, Scott W., Armstrong, Scott A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501293/
https://ncbi.nlm.nih.gov/pubmed/28202522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2374
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