MLL-AF9-Induced Leukemogenesis Requires Co-Expression of the Wild Type Mll Allele

Oncogenic fusion proteins are capable of initiating tumorigenesis but the role of their wild-type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) gene undergoes chromosomal translocations, resulting in the formation of oncogenic MLL fusion proteins (MLL-FPs). Here...

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Autori principali: Thiel, Austin T., Blessington, Peter, Zou, Tao, Feather, Danielle, Wu, Xinjiang, Yan, Jizhou, Zhang, Hui, Liu, Zuguo, Ernst, Patricia, Koretzky, Gary A., Hua, Xianxin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830208/
https://ncbi.nlm.nih.gov/pubmed/20159607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.12.034
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