CBX8, a Polycomb Group Protein, is Essential for MLL-AF9-Induced Leukemogenesis

Chromosomal translocations involving the mixed lineage leukemia (MLL) gene lead to the development of acute leukemias. Constitutive HOX gene activation by MLL fusion proteins is required for MLL-mediated leukemogenesis; however, the underlying mechanisms remain elusive. Here, we show that chromobox...

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Main Authors: Tan, Jiaying, Jones, Morgan, Koseki, Haruhiko, Nakayama, Manabu, Muntean, Andrew, Maillard, Ivan, Hess, Jay L.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220883/
https://ncbi.nlm.nih.gov/pubmed/22094252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.09.008
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