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CBX8, a Polycomb Group Protein, is Essential for MLL-AF9-Induced Leukemogenesis
Chromosomal translocations involving the mixed lineage leukemia (MLL) gene lead to the development of acute leukemias. Constitutive HOX gene activation by MLL fusion proteins is required for MLL-mediated leukemogenesis; however, the underlying mechanisms remain elusive. Here, we show that chromobox...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220883/ https://ncbi.nlm.nih.gov/pubmed/22094252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.09.008 |
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