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Polycomb repressive complex 2 is required for MLL-AF9 leukemia

A growing body of data suggests the importance of epigenetic mechanisms in cancer. Polycomb repressive complex 2 (PRC2) has been implicated in self-renewal and cancer progression, and its components are overexpressed in many cancers. However, its role in cancer development and progression remains un...

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Main Authors: Neff, Tobias, Sinha, Amit U., Kluk, Michael J., Zhu, Nan, Khattab, Mohamed H., Stein, Lauren, Xie, Huafeng, Orkin, Stuart H., Armstrong, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324004/
https://ncbi.nlm.nih.gov/pubmed/22396593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202258109
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