Inactivation of Eed Impedes MLL-AF9 Mediated Leukemogenesis Through Cdkn2a-Dependent and Cdkn2a-Independent Mechanisms in a Murine Model

Polycomb Repressive Complex 2 (PRC2) is a chromatin regulator with central roles in development and cancer. The canonical function of PRC2 is the tri-methylation of histone 3 on lysine residue 27. This epigenetic modification is associated with gene silencing. Both tumor suppressor and oncogenic fun...

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Pubblicato in:Exp Hematol
Autori principali: Danis, Etienne, Yamauchi, Taylor, Echanique, Kristen, Haladyna, Jessica, Kalkur, Roshni, Riedel, Simone, Zhu, Nan, Xie, Huafeng, Bernt, Kathrin M., Orkin, Stuart H., Armstrong, Scott A., Neff, Tobias
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630114/
https://ncbi.nlm.nih.gov/pubmed/26118502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2015.06.005
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