Inactivation of Eed Impedes MLL-AF9 Mediated Leukemogenesis Through Cdkn2a-Dependent and Cdkn2a-Independent Mechanisms in a Murine Model

Polycomb Repressive Complex 2 (PRC2) is a chromatin regulator with central roles in development and cancer. The canonical function of PRC2 is the tri-methylation of histone 3 on lysine residue 27. This epigenetic modification is associated with gene silencing. Both tumor suppressor and oncogenic fun...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Exp Hematol
Main Authors: Danis, Etienne, Yamauchi, Taylor, Echanique, Kristen, Haladyna, Jessica, Kalkur, Roshni, Riedel, Simone, Zhu, Nan, Xie, Huafeng, Bernt, Kathrin M., Orkin, Stuart H., Armstrong, Scott A., Neff, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630114/
https://ncbi.nlm.nih.gov/pubmed/26118502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2015.06.005
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados