Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation

Disruptor of telomeric silencing 1-like (Dot1l) is a histone 3 lysine 79 methyltransferase. Studies of constitutive Dot1l knockout mice show that Dot1l is essential for embryonic development and prenatal hematopoiesis. DOT1L also interacts with translocation partners of Mixed Lineage Leukemia (MLL)...

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Bibliografske podrobnosti
Main Authors: Jo, Stephanie Y., Granowicz, Eric M., Maillard, Ivan, Thomas, Dafydd, Hess, Jay L.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Hematopoiesis and Stem Cells
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100687/
https://ncbi.nlm.nih.gov/pubmed/21398221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-327668
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