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Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
Disruptor of telomeric silencing 1-like (Dot1l) is a histone 3 lysine 79 methyltransferase. Studies of constitutive Dot1l knockout mice show that Dot1l is essential for embryonic development and prenatal hematopoiesis. DOT1L also interacts with translocation partners of Mixed Lineage Leukemia (MLL)...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100687/ https://ncbi.nlm.nih.gov/pubmed/21398221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-327668 |
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