LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Mixed lineage leukemia (MLL) represents a genetically distinct and aggressive subset of human acute leukemia carrying chromosomal translocations of the MLL gene. These translocations result in oncogenic fusions that mediate aberrant recruitment of the transcription machinery to MLL target genes. The...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: El Ashkar, Sara, Schwaller, Juerg, Pieters, Tim, Goossens, Steven, Demeulemeester, Jonas, Christ, Frauke, Van Belle, Siska, Juge, Sabine, Boeckx, Nancy, Engelman, Alan, Van Vlierberghe, Pieter, Debyser, Zeger, De Rijck, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755044/
https://ncbi.nlm.nih.gov/pubmed/29084774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-786962
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