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LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis
Mixed lineage leukemia (MLL) represents a genetically distinct and aggressive subset of human acute leukemia carrying chromosomal translocations of the MLL gene. These translocations result in oncogenic fusions that mediate aberrant recruitment of the transcription machinery to MLL target genes. The...
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| Veröffentlicht in: | Blood |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5755044/ https://ncbi.nlm.nih.gov/pubmed/29084774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-786962 |
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