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LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Mixed lineage leukemia (MLL) represents a genetically distinct and aggressive subset of human acute leukemia carrying chromosomal translocations of the MLL gene. These translocations result in oncogenic fusions that mediate aberrant recruitment of the transcription machinery to MLL target genes. The...

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Publicat a:Blood
Autors principals: El Ashkar, Sara, Schwaller, Juerg, Pieters, Tim, Goossens, Steven, Demeulemeester, Jonas, Christ, Frauke, Van Belle, Siska, Juge, Sabine, Boeckx, Nancy, Engelman, Alan, Van Vlierberghe, Pieter, Debyser, Zeger, De Rijck, Jan
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755044/
https://ncbi.nlm.nih.gov/pubmed/29084774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-786962
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