LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Mixed lineage leukemia (MLL) represents a genetically distinct and aggressive subset of human acute leukemia carrying chromosomal translocations of the MLL gene. These translocations result in oncogenic fusions that mediate aberrant recruitment of the transcription machinery to MLL target genes. The...

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Bibliographic Details
Published in:Blood
Main Authors: El Ashkar, Sara, Schwaller, Juerg, Pieters, Tim, Goossens, Steven, Demeulemeester, Jonas, Christ, Frauke, Van Belle, Siska, Juge, Sabine, Boeckx, Nancy, Engelman, Alan, Van Vlierberghe, Pieter, Debyser, Zeger, De Rijck, Jan
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2018
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755044/
https://ncbi.nlm.nih.gov/pubmed/29084774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-786962
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