LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Mixed lineage leukemia (MLL) represents a genetically distinct and aggressive subset of human acute leukemia carrying chromosomal translocations of the MLL gene. These translocations result in oncogenic fusions that mediate aberrant recruitment of the transcription machinery to MLL target genes. The...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Blood
Main Authors: El Ashkar, Sara, Schwaller, Juerg, Pieters, Tim, Goossens, Steven, Demeulemeester, Jonas, Christ, Frauke, Van Belle, Siska, Juge, Sabine, Boeckx, Nancy, Engelman, Alan, Van Vlierberghe, Pieter, Debyser, Zeger, De Rijck, Jan
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2018
Assuntos:
Hematopoiesis and Stem Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755044/
https://ncbi.nlm.nih.gov/pubmed/29084774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-786962
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares