Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation

Lens epithelium-derived growth factor/p75 (LEDGF/p75, or PSIP1) is a transcriptional coactivator that tethers other proteins to gene bodies. The chromatin tethering function of LEDGF/p75 is hijacked by HIV integrase to ensure viral integration at sites of active transcription. LEDGF/p75 is also impo...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sharma, Subhalakshmi, Čermáková, Kateřina, De Rijck, Jan, Demeulemeester, Jonas, Fábry, Milan, El Ashkar, Sara, Van Belle, Siska, Lepšík, Martin, Tesina, Petr, Duchoslav, Vojtěch, Novák, Petr, Hubálek, Martin, Srb, Pavel, Christ, Frauke, Řezáčová, Pavlína, Hodges, H. Courtney, Debyser, Zeger, Veverka, Václav
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065015/
https://ncbi.nlm.nih.gov/pubmed/29997176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803909115
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