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Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras

The capacity to integrate transgenes into the host cell genome makes retroviral vectors an interesting tool for gene therapy. Although stable insertion resulted in successful correction of several monogenic disorders, it also accounts for insertional mutagenesis, a major setback in otherwise success...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Vranckx, Lenard S., Demeulemeester, Jonas, Debyser, Zeger, Gijsbers, Rik
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082951/
https://ncbi.nlm.nih.gov/pubmed/27788138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164167
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