LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

Lens epithelium–derived growth factor (LEDGF/p75) is a cellular cofactor of HIV-1 integrase (IN) that interacts with IN through its IN binding domain (IBD) and tethers the viral pre-integration complex to the host cell chromatin. Here we report the generation of a human somatic LEDGF/p75 knockout ce...

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Bibliographic Details
Main Authors: Schrijvers, Rik, De Rijck, Jan, Demeulemeester, Jonas, Adachi, Noritaka, Vets, Sofie, Ronen, Keshet, Christ, Frauke, Bushman, Frederic D., Debyser, Zeger, Gijsbers, Rik
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291655/
https://ncbi.nlm.nih.gov/pubmed/22396646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002558
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