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MLL fusion protein–driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction
MLL rearrangements are common in leukemia and considered an adverse risk factor. Through interactions with the polymerase-associated factor complex (PAFc), mixed lineage leukemia (MLL) fusion proteins activate genes critical for blocking differentiation, such as HOXA9. Here we investigate whether th...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society of Hematology
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3772498/ https://ncbi.nlm.nih.gov/pubmed/23900238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-486977 |
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