MLL fusion protein–driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction

MLL rearrangements are common in leukemia and considered an adverse risk factor. Through interactions with the polymerase-associated factor complex (PAFc), mixed lineage leukemia (MLL) fusion proteins activate genes critical for blocking differentiation, such as HOXA9. Here we investigate whether th...

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Detalhes bibliográficos
Main Authors: Muntean, Andrew G., Chen, Wei, Jones, Morgan, Granowicz, Eric M., Maillard, Ivan, Hess, Jay L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772498/
https://ncbi.nlm.nih.gov/pubmed/23900238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-486977
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