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The PHD fingers of MLL block MLL fusion protein–mediated transformation

Chromosomal translocations involving the mixed lineage leukemia (MLL) gene are associated with aggressive acute lymphoid and myeloid leukemias. These translocations are restricted to an 8.3-kb breakpoint region resulting in fusion of amino terminal MLL sequences in frame to 1 of more than 60 differe...

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Hlavní autoři: Muntean, Andrew G., Giannola, Diane, Udager, Aaron M., Hess, Jay L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597135/
https://ncbi.nlm.nih.gov/pubmed/18796627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-134056
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