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Protein Interactions of the MLL PHD Fingers Modulate MLL Target Gene Regulation in Human Cells
The PHD fingers of the human MLL and Drosophila trx proteins have strong amino acid sequence conservation but their function is unknown. We have determined that these fingers mediate homodimerization and binding of MLL to Cyp33, a nuclear cyclophilin. These two proteins interact in vitro and in vivo...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC100280/ https://ncbi.nlm.nih.gov/pubmed/11313484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.10.3589-3597.2001 |
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