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Loss of MLL PHD-finger-3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization

Reciprocal chromosomal translocations at the MLL gene locus result in expression of novel fusion proteins such as MLL-ENL associated with leukemia. The three PHD finger cassette, one of the highly conserved domains in MLL, is absent in all fusion proteins. This domain has been shown to interact with...

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Sonraí Bibleagrafaíochta
Main Authors: Chen, Jing, Santillan, Donna A., Koonce, Mark, Wei, Wei, Luo, Roger, Thirman, Michael J., Zeleznik-Le, Nancy J., Diaz, Manuel O.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734520/
https://ncbi.nlm.nih.gov/pubmed/18676843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6514
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