WEE1 is a validated target of the microRNA miR-17-92 cluster in leukemia

per Brockway, Sonia, Zeleznik-Le, Nancy J.
Publicat a Cancer Genet (2015)

Glycogen synthase kinase-3 and Leukemia: Restoring the balance

per Birch, Noah W., Zeleznik-Le, Nancy J.
Publicat 2010

MicroRNAs in Leukemias: Emerging Diagnostic Tools and Therapeutic Targets

per Mian, Yousaf A., Zeleznik-Le, Nancy J.
Publicat 2010

Breaking the LSD1/KDM1A Addiction: Therapeutic Targeting of the Epigenetic Modifier in AML

per Lokken, Alyson A., Zeleznik-Le, Nancy J.
Publicat 2012

The miR-17~92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1

per Mian, Yousaf A., Zeleznik-Le, Nancy J.
Publicat a Leuk Res (2016)

MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)

per Osaka, Mitsuhiko, Rowley, Janet D., Zeleznik-Le, Nancy J.
Publicat 1999

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

per Xia, Zhen-Biao, Anderson, Melanie, Diaz, Manuel O., Zeleznik-Le, Nancy J.
Publicat 2003

Adolescent binge-pattern alcohol exposure alters genome-wide DNA methylation patterns in the hypothalamus of alcohol-naïve male offspring

per Asimes, AnnaDorothea, Torcaso, Audrey, Pinceti, Elena, Kim, Chun K, Zeleznik-Le, Nancy J., Pak, Toni R.
Publicat a Alcohol (2016)

NKG2D signaling certifies effector CD8 T cells for memory formation

per Perez, Cynthia, Prajapati, Kushal, Burke, Brianna, Plaza-Rojas, Lourdes, Zeleznik-Le, Nancy J., Guevara-Patino, Jose A.
Publicat a J Immunother Cancer (2019)

Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells

per Zook, Erin C., Krishack, Paulette A., Zhang, Shubin, Zeleznik-Le, Nancy J., Firulli, Anthony B., Witte, Pamela L., Le, Phong T.
Publicat 2011

Loss of MLL PHD-finger-3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization

per Chen, Jing, Santillan, Donna A., Koonce, Mark, Wei, Wei, Luo, Roger, Thirman, Michael J., Zeleznik-Le, Nancy J., Diaz, Manuel O.
Publicat 2008

Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes

per Chang, Ming-Jin, Wu, Hongyu, Achille, Nicholas J., Reisenauer, Mary Rose, Chou, Chau-Wen, Zeleznik-Le, Nancy J., Hemenway, Charles S., Zhang, Wenzheng
Publicat 2010

The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27(kip1)) expression

per Xia, Zhen-Biao, Popovic, Relja, Chen, Jing, Theisler, Catherine, Stuart, Tara, Santillan, Donna A., Erfurth, Frank, Diaz, Manuel O., Zeleznik-Le, Nancy J.
Publicat 2005

Structure of the MLL CXXC domain – DNA complex and its functional role in MLL-AF9 leukemia

per Cierpicki, Tomasz, Risner, Laurie E., Grembecka, Jolanta, Lukasik, Stephen M., Popovic, Relja, Omonkowska, Monika, Shultis, David S., Zeleznik-Le, Nancy J., Bushweller, John H.
Publicat 2009

Functional Specificity of CpG DNA-binding CXXC Domains in Mixed Lineage Leukemia

per Risner, Laurie E., Kuntimaddi, Aravinda, Lokken, Alyson A., Achille, Nicholas J., Birch, Noah W., Schoenfelt, Kelly, Bushweller, John H., Zeleznik-Le, Nancy J.
Publicat 2013

Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential

per Kuntimaddi, Aravinda, Achille, Nicholas J., Thorpe, Jeremy, Lokken, Alyson A., Singh, Ritambhara, Hemenway, Charles S., Adli, Mazhar, Zeleznik-Le, Nancy J., Bushweller, John H.
Publicat a Cell Rep (2015)

BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity

per Schmidt, Charles R., Achille, Nicholas J., Kuntimaddi, Aravinda, Boulton, Adam M., Leach, Benjamin I., Zhang, Shubin, Zeleznik-Le, Nancy J., Bushweller, John H.
Publicat a Blood Cancer Discov (2020)

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

per Sobulo, Olatoyosi M., Borrow, Julian, Tomek, Ronald, Reshmi, Shalini, Harden, Alanna, Schlegelberger, Brigitte, Housman, David, Doggett, Norman A., Rowley, Janet D., Zeleznik-Le, Nancy J.
Publicat 1997

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression

per Erfurth, Frank E., Popovic, Relja, Grembecka, Jolanta, Cierpicki, Tomasz, Theisler, Catherine, Xia, Zhen-Biao, Stuart, Tara, Diaz, Manuel O., Bushweller, John H., Zeleznik-Le, Nancy J.
Publicat 2008

p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL‐leukemia

per Zhang, Jun, Seet, Christopher S., Sun, Clare, Li, Jing, You, Dewen, Volk, Andrew, Breslin, Peter, Li, Xingyu, Wei, Wei, Qian, Zhijian, Zeleznik-Le, Nancy J., Zhang, Zhou, Zhang, Jiwang
Publicat 2013