p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL‐leukemia

MLL (mixed‐lineage leukemia)‐fusion genes induce the development of leukemia through deregulation of normal MLL target genes, such as HOXA9 and MEIS1. Both HOXA9 and MEIS1 are required for MLL‐fusion gene‐induced leukemogenesis. Co‐expression of HOXA9 and MEIS1 induces acute myeloid leukemia (AML) s...

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Bibliographic Details
Main Authors: Zhang, Jun, Seet, Christopher S., Sun, Clare, Li, Jing, You, Dewen, Volk, Andrew, Breslin, Peter, Li, Xingyu, Wei, Wei, Qian, Zhijian, Zeleznik-Le, Nancy J., Zhang, Zhou, Zhang, Jiwang
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2013
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898829/
https://ncbi.nlm.nih.gov/pubmed/23988911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.07.011
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