Therapeutic targeting of MLL degradation pathways in MLL-rearranged leukemia

Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Despite similar expression at the mRNA level from the wild-type and chimeric MLL alleles, the chimeric protein is more stable. We report that UBE2O funct...

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Publicado no:Cell
Main Authors: Liang, Kaiwei, Volk1, Andrew G., Haug, Jeffrey S., Marshall, Stacy A., Woodfin, Ashley R., Bartom, Elizabeth T., Gilmore, Joshua M., Florens, Laurence, Washburn, Michael P., Sullivan, Kelly D., Espinosa, Joaquin M., Cannova, Joseph, Zhang, Jiwang, Smith, Edwin R., Crispino, John D., Shilatifard, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351781/
https://ncbi.nlm.nih.gov/pubmed/28065413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.12.011
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