Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia

Chromosomal translocations of the Mixed-lineage leukemia 1 (MLL1) gene generate MLL chimeras that drive the pathogenesis of acute myeloid and lymphoid leukemia. The untranslocated MLL1 is a substrate for proteolytic cleavage by the endopeptidase threonine aspartase 1 (taspase1); however, the biologi...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Zhao, Zibo, Wang, Lu, Volk, Andrew G., Birch, Noah W., Stoltz, Kristen L., Bartom, Elizabeth T., Marshall, Stacy A., Rendleman, Emily J., Nestler, Carson M., Shilati, Joseph, Schiltz, Gary E., Crispino, John D., Shilatifard, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317322/
https://ncbi.nlm.nih.gov/pubmed/30573454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.319830.118
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