An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells

Chromatin regulators control cellular differentiation by orchestrating dynamic developmental gene expression programs, and hence, malfunctions in the regulation of chromatin state contribute to both developmental disorders and disease state. Mll4 (Kmt2d), a member of the COMPASS (COMplex of Proteins...

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Bibliografiset tiedot
Julkaisussa:Sci Adv
Päätekijät: Cao, Kaixiang, Collings, Clayton K., Morgan, Marc A., Marshall, Stacy A., Rendleman, Emily J., Ozark, Patrick A., Smith, Edwin R., Shilatifard, Ali
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Association for the Advancement of Science 2018
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Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796793/
https://ncbi.nlm.nih.gov/pubmed/29404406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aap8747
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