Resetting the Epigenetic Balance of Polycomb and COMPASS Function at Enhancers for Cancer Therapy

MLL3 (also named KMT2C) is a COMPASS subunit that implements H3K4 mono-methylation at gene enhancers. KMT2C frequently incurs point-mutations across a range of human tumors, nevertheless precisely how these lesions alter MLL3 function and contribute to oncogenesis is unclear. Here we report a cancer...

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Détails bibliographiques
Publié dans:Nat Med
Auteurs principaux: Wang, Lu, Zhao, Zibo, Ozark, Patrick Alexander, Fantini, Damiano, Marshall, Stacy A., Rendleman, Emily J., Cozzolino, Kira A., Louis, Nundia, He, Xingyao, Morgan, Marc A., Takahashi, Yoh-hei, Collings, Clayton K., Smith, Edwin R., Ntziachristos, Panagiotis, Savas, Jeffrey N., Zou, Lihua, Hashizume, Rintaro, Meeks, Joshua J., Shilatifard, Ali
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055231/
https://ncbi.nlm.nih.gov/pubmed/29785026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0034-6
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