Functional Specificity of CpG DNA-binding CXXC Domains in Mixed Lineage Leukemia

The MLL CXXC domain binds nonmethylated CpG-containing DNA and is essential for the oncogenic properties of MLL fusion proteins. To determine potential functional promiscuity of similar DNA binding domains, we replaced the MLL CXXC domain in the context of the leukemogenic MLL-AF9 fusion with CXXC d...

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Bibliographic Details
Main Authors: Risner, Laurie E., Kuntimaddi, Aravinda, Lokken, Alyson A., Achille, Nicholas J., Birch, Noah W., Schoenfelt, Kelly, Bushweller, John H., Zeleznik-Le, Nancy J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795288/
https://ncbi.nlm.nih.gov/pubmed/23990460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.474858
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