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The miR-17~92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1
Mixed lineage leukemias have a relatively poor prognosis and arise as a result of translocations between the MLL (KMT2A) gene and one of multiple partner genes. Downstream targets of MLL are aberrantly upregulated and include the developmentally important HOX genes and MEIS1, as well as multiple mic...
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| Publicado no: | Leuk Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4899285/ https://ncbi.nlm.nih.gov/pubmed/27123834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2016.04.006 |
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