BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity

MLL is a target of chromosomal translocations in acute leukemias with poor prognosis. The common MLL fusion partner AF9 (MLLT3) can directly bind to AF4, DOT1L, BCOR, and CBX8. To delineate the relevance of BCOR and CBX8 binding to MLL-AF9 for leukemogenesis, here we determine protein structures of...

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Detalhes bibliográficos
Publicado no:Blood Cancer Discov
Main Authors: Schmidt, Charles R., Achille, Nicholas J., Kuntimaddi, Aravinda, Boulton, Adam M., Leach, Benjamin I., Zhang, Shubin, Zeleznik-Le, Nancy J., Bushweller, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497807/
https://ncbi.nlm.nih.gov/pubmed/32954361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0036
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