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MLL fusion partner AF9 is an intrinsically disordered transcriptional regulator which recruits multiple partners via coupled folding and binding
Mixed Lineage Leukemia (MLL) fusion proteins cause oncogenic transformation of hematopoietic cells by constitutive recruitment of elongation factors to HOX promoters, resulting in over-expression of target genes. The structural basis of transactivation by MLL fusion partners remains undetermined. We...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545106/ https://ncbi.nlm.nih.gov/pubmed/23260655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.11.011 |
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