Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair

The most frequent rearrangement of the human MLL gene fuses MLL to AF4 resulting in high-risk infant B-cell acute lymphoblastic leukemia (B-ALL). MLL fusions are also hallmark oncogenic events in secondary acute myeloid leukemia. They are a direct consequence of mis-repaired DNA double strand breaks...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Castaño, Julio, Herrero, Ana B., Bursen, Aldeheid, González, Federico, Marschalek, Rolf, Gutiérrez, Norma C., Menendez, Pablo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058691/
https://ncbi.nlm.nih.gov/pubmed/27119507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8938
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