Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4–MLL Fusion Protein

We have recently demonstrated that Taspase1-mediated cleavage of the AF4–MLL oncoprotein results in the formation of a stable multiprotein complex which forms the key event for the onset of acute proB leukemia in mice. Therefore, Taspase1 represents a conditional oncoprotein in the context of t(4;11...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:EBioMedicine
Asıl Yazarlar: Sabiani, Samaneh, Geppert, Tim, Engelbrecht, Christian, Kowarz, Eric, Schneider, Gisbert, Marschalek, Rolf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2015
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486195/
https://ncbi.nlm.nih.gov/pubmed/26137584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.04.009
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller