Bioassays to Monitor Taspase1 Function for the Identification of Pharmacogenetic Inhibitors

BACKGROUND: Threonine Aspartase 1 (Taspase1) mediates cleavage of the mixed lineage leukemia (MLL) protein and leukemia provoking MLL-fusions. In contrast to other proteases, the understanding of Taspase1's (patho)biological relevance and function is limited, since neither small molecule inhibi...

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Main Authors: Knauer, Shirley K., Fetz, Verena, Rabenstein, Jens, Friedl, Sandra, Hofmann, Bettina, Sabiani, Samaneh, Schröder, Elisabeth, Kunst, Lena, Proschak, Eugen, Thines, Eckhard, Kindler, Thomas, Schneider, Gisbert, Marschalek, Rolf, Stauber, Roland H., Bier, Carolin
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102056/
https://ncbi.nlm.nih.gov/pubmed/21647428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018253
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