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Loss of MLL PHD-finger-3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization
Reciprocal chromosomal translocations at the MLL gene locus result in expression of novel fusion proteins such as MLL-ENL associated with leukemia. The three PHD finger cassette, one of the highly conserved domains in MLL, is absent in all fusion proteins. This domain has been shown to interact with...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734520/ https://ncbi.nlm.nih.gov/pubmed/18676843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6514 |
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